Total synthesis of (±)-cortistatin J from furan.
نویسندگان
چکیده
A concise, diastereoselective total synthesis of (±)-cortistatin J has been completed in 20 steps from furan. Key steps include an intramolecular [4 + 3] cyclization of a disubstituted furan with a (Z)-2-(trialkylsilyloxy)-2-enal to construct the tetracyclic core and a (Z)-vinylsilane/iminium ion cyclization to form the A ring.
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ورودعنوان ژورنال:
- Journal of the American Chemical Society
دوره 133 32 شماره
صفحات -
تاریخ انتشار 2011